Trial design
Split by 3 values across our medical research reporting, including randomisation, blinding and control arms, drawing on the 19 reports filed on it so far.
Natera partners with Angiex on cancer trial
Natera has partnered with Angiex to evaluate its Signatera blood test in a phase 1 trial of the cancer drug AGX101.
mRNA cancer vaccine trial succeeds
A personalized mRNA vaccine for melanoma from Moderna and Merck has shown clinical success, offering a potential boost for the mRNA field after...
Alnylam defends silencer drugs after
Alnylam defends its RNAi drugs after AstraZeneca's heart disease trial failure, arguing they work even for patients on stabilizer therapies.
Transcatheter Tricuspid Repair Cuts Death
The TRIC-I-HF trial shows transcatheter tricuspid valve repair significantly reduces all-cause death and heart failure hospitalization in high-risk
AstraZeneca, Amgen's Tezspire succeeds in
AstraZeneca and Amgen's Tezspire succeeded in a Phase 3 trial for eosinophilic esophagitis, potentially expanding the label for the immunology drug.
IV Iron Cuts Transfusions in Cardiac Surgery
A trial found intravenous iron before cardiac surgery reduced transfusion needs and slightly increased days at home.
AusperBio raises $120M for hepatitis B trial
AusperBio Therapeutics raised $120 million in a series C round led by RA Capital to advance its hepatitis B drug candidate AHB-137 into phase 3...
EPIDAURUS trial halted over bleeding risk
The EPIDAURUS trial testing potent antiplatelet drugs with anticoagulants in atrial fibrillation and acute coronary syndrome patients was stopped...
BioNTech-Genentech cancer vaccine trial
BioNTech and Genentech ended a trial of their mRNA cancer vaccine after more deaths occurred in the vaccinated group versus the observation group.
DOACs Win First Trial for Lower-Risk Afib
The SINGLE-AF trial found direct oral anticoagulants reduced cardiovascular events in atrial fibrillation patients with a single stroke risk factor...
AstraZeneca halts cancer drug trial in setback
AstraZeneca halts cancer drug trial in setback. A target trial emulation of adults with serious mental illness (SMI) found GLP-1 receptor agonists...
Revolution Medicines' Rasonque Approved for Pancreatic Cancer
The FDA has approved Rasonque, a new pancreatic cancer drug by Revolution Medicines, marking the first treatment to target a genetic cause of the...
TALENTOP trial: conversion surgery in advanced HCC
The TALENTOP study, a multicentre, open-label, randomised phase 3 trial, compares liver resection after atezolizumab and bevacizumab with maintenance...
Moderna-Merck Cancer Vaccine
Moderna and Merck's individualized cancer vaccine shows promise in Phase 3 trial for melanoma
UK feasibility trial finds psilocybin therapy safe for resistant depression
A 2026 feasibility study delivering psilocybin-assisted therapy within the NHS reported high adherence and no safety concerns, raising questions...
Capricor’s Duchenne Drug Study Highlights the Challenges of Rare Disease Trials
The FDA's recent decision on Capricor’s deramiocel for Duchenne muscular dystrophy underscores the complexities of rare disease clinical trials...
FDA Commissioner Nominee Announced, mRNA Cancer Vaccine Shows Promise
The White House is expected to nominate Heidi Overton as the next commissioner of the U.S. Food and Drug Administration. Meanwhile, a late-stage...
Eyepoint Study Results Disappoint for Vision Treatment
Eyepoint's experimental treatment for age-related blindness fails to meet primary goal in Phase 3 clinical trial.
AstraZeneca Lung Cancer Trial Setback, Falling U.S. Drug Prices
AstraZeneca discontinues a late-stage trial for its experimental drug volrustomig, while prescription drug prices in the U.S. experience a...